MHC-HM421TP | 价格

MHC-HM421TP-100μg / 询价

MHC-HM421TP-500μg / 询价

MHC-HM421TP-500μgx2 / 询价

PE-Labeled Human HLA-A*11:01&B2M&KRAS G12V (VVVGAVGVGK) Tetramer Protein

产品信息(Product Info)
表达区间及表达系统(Source)

Recombinant PE-Labeled Human HLA-A*11:01&B2M&KRAS G12V (VVVGAVGVGK) Tetramer Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus. PE-labeled Human HLA-A*11:01&B2M&KRAS G12V (VVVGAVGVGK) Tetramer is assembled by biotinylated monomer and PE-Labeled streptavidin.
It contains Gly25-Thr305(HLA-A*11:01), Ile21-Met119(B2M) and VVVGAVGVGK peptide [Accession | AAV53343.1(HLA-A*11:01)&P61769(B2M)&VVVGAVGVGK].

波长(Wavelength)

Excitation Wavelength: 488 nm / 561 nm

Emission Wavelength: 575 nm

内毒素(Endotoxin)

Less than 1 EU per μg by the LAL method.

制剂(Formulation)

Supplied as 0.22 μm filtered solution in PBS, 0.2% BSA (pH 7.4).

存储(Storage)

Valid for 6 months from date of receipt when stored at -80°C.; Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

产品数据(Assay Data)
ELISA Data

Immobilized PE-labeled Human HLA-A*11:01&B2M&KRAS G12V (VVVGAVGVGK) Tetramer, His Tag at 0.5μg/ml(100μl/well) on the plate. Dose response curve for Anti-B2M Antibody, mFc Tag with the EC50 of 12.8ng/ml determined by ELISA (QC Test).

背景(Background)

Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail.

分子别名(Synonyms)

MHC; KRAS; K-Ras 2; KRAS2; C-K-RAS; CFC2; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B; KRAS1; KRAS2; NS; NS3; RASK2; GTPase Kras; KI-RAS; RALD

文献(References)

(1) Wu HZ, Xiao JQ, Xiao SS, Cheng Y. KRAS: A Promising Therapeutic Target for Cancer Treatment. Curr Top Med Chem. 2019;19(23):2081-2097. doi: 10.2174/1568026619666190905164144. PMID: 31486755.